The information contained in this section has been procured from the Celiac Disease Foundation and

It is all for educational purposes and not intended to be taken as medical advice.

Long-Term Health Effects

People with celiac disease have a 2x greater risk of developing coronary artery disease, and a 4x greater risk of developing small bowel cancers.

The treatment burden of celiac disease is comparable to end-stage renal disease, and the partner burden is comparable to caring for a patient with cancer. 1 2

Untreated celiac disease can lead to the development of other autoimmune disorders like Type I diabetes and multiple sclerosis (MS), and many other conditions, including dermatitis herpetiformis (an itchy skin rash), anemia, osteoporosis, infertility and miscarriage, neurological conditions like epilepsy and migraines, short stature, heart disease and intestinal cancers.



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Undiagnosed or Untreated Celiac Disease Can Lead to Long-Term Health Conditions

  • Iron deficiency anemia

  • Early onset osteoporosis or osteopenia

  • Infertility and miscarriage

  • Lactose intolerance

  • Vitamin and mineral deficiencies

  • Central and peripheral nervous system disorders

  • Pancreatic insufficiency

  • Intestinal lymphomas and other GI cancers (malignancies)

  • Gall bladder malfunction

  • Neurological manifestations, including ataxia, epileptic seizures, dementia, migraine, neuropathy, myopathy and multifocal leucoencephalopathy

Other Autoimmune Disorders

In a 1999 study, Ventura, et al. found that for people with celiac disease, the later the age of diagnosis, the greater the chance of developing another autoimmune disorder.

Autoimmune and Other Conditions Associated with Celiac Disease

AUTOIMMUNE CONDITION                                               PREVALENCE IN CD POPULATION


Anemia                                                                 12-69%

Autoimmune Hepatitis                                 2%

Autoimmune Thyroid Disease                  26%

Chronic fatigue syndrome                          2%

Dermatitis Herpetiformis                           25%

Down syndrome                                              12%

Gluten ataxia                                                     10-12%

Idiopathic Dilated Cardiomyapathy      5.7%

Juvenile Idiopathic Arthritis                     1.5-6.6%

Liver Disease                                                    10%

Lymphocytic Colitis                                       15-27%

Microscopic Colitis                                        4%

Peripheral Neuropathy                               10-12%

Primary Bilary Cirrhosis                             3%

Sjögren’s Syndrome                                      3%

Type 1 Diabetes                                              8-10%

Unexplained infertility                                12%

Blood. 2007 Jan 15; 109(2): 412–421, Biomed Res Int. 2013; 2013: 127589, Expert Rev Gastroenterol Hepatol. 2010;4(6):767-780, PMC 2009; 55:349–365, Gut 49.4 (2001): 502-505, Ravelli, Lancet; 2007, 369(9563):767-78, Bai, et al. “World Gastroenterology Organization Practice Guidelines:.” World Gastroenterology Organization.

Sources: Celiac Disease Foundation